Sex differences in extrastriatal dopamine D-sub-2-like receptors in the human brain. |
Author: |
Kaasinen,-Valtteri; Nagren,-Kjell; Hietala,-Jarmo; Farde,-Lars; Rinne,-Juha-O
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Author Background: |
U Turku, Dept of Neurology, Turku, Finland
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Date |
2/2001
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Type |
Journal
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Journal Title: |
American-Journal-of-Psychiatry
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Volume/Pages |
Vol 158(2): 308-311
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Publisher |
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Subject Matter |
Research, Gender, Brain; Dopamine; Human Sex Differences; Neural Receptors
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Population |
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Pedagogies |
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Abstract |
Examined gender differences in extrastriatal dopamine D-sub-2-like receptor levels in the human brain in vivo. A high-affinity radioligand for extrastriatal D-sub-2-like receptors and a 3-dimensional positron emission tomography system were used to measure D-sub-2-like receptor binding potentials in frontal cortex, temporal cortex, and thalamus in 24 healthy men and women (aged 33-74 yrs). Women had higher D-sub-2-like receptor binding potentials than men in the 3 brain regions studied, and the difference in the frontal cortex was statistically significant. In a more detailed regional analysis, the difference between the sexes was most pronounced for the left and right anterior cingulate cortex. This study provides in vivo evidence for a gender difference in dopamine D-sub-2-like receptor levels, which could be reflected in gender-associated differences in clinical disorders linked to the dopamine system. (PsycINFO Database Record (c) 2000 APA, all rights reserved)
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