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Multiculturalism and Social Work | San Francisco State University

Effects of smoking during antipsychotic withdrawal in patients with chronic schizophrenia.

Author: Apud,-Jose-A; Egan,-Michael-F; Wyatt,-Richard-J
Author Background:
Date 12/2000
Type Journal
Journal Title: Schizophrenia-Research
Volume/Pages Vol 46(2-3): 119-127
Subject Matter Psychiatric-Symptoms; *Psychopathology-; *Schizophrenia-; *Tobacco-Smoking; *Treatment-Termination, Drug-Therapy; Neuroleptic-Drugs, Research
Abstract Assessed the effect of smoking on ratings of psychopathology for 30 days following discontinuation of typical antipsychotic medication in 101 treatment-resistant adult inpatients with schizophrenia. Patients were rated daily on the Psychiatric Symptom Assessment Scale. At baseline, ratings for Verbal Positive, Paranoia and Loss of Function were higher in smokers than nonsmokers, with a statistically significant difference only for the Verbal Positive cluster. Male non-smokers had the lowest psychopathology ratings at baseline. There were no gender differences in Anxiety/Depression, Behavior Positive, Deficit Symptoms or Mannerisms (abnormal involuntary movements). After medication discontinuation, analysis showed a time effect for all variables and a group effect for Verbal Positive, Paranoia, and Loss of Function. Post-hoc comparisons showed significantly higher ratings for smokers at week 1 for Paranoia; there were no differences observed at later time points. In conclusion, smokers had more positive symptoms at baseline and were apparently more functionally impaired than non-smokers, a difference not evident after a 30 day medication discontinuation period. (PsycINFO Database Record (c) 2000 APA, all rights reserved)